zucker rats diabetes

Male Zucker diabetic fatty fa/fa (ZDF) rats develop obesity and insulin resistance at a young age, and then with aging, progressively develop hyperglycemia. Would you like email updates of new search results? Over time, the pancreas becomes exhausted, insulin secretion decreases (as it does in human diabetics) and plasma glucose increases in the face of insulin resistance. The biobreeding rat (a.k.a.  |  2007 Feb;292(2):E549-60. Conclusions: The enlarged islets of Zucker fatty diabetes mellitus rats, which are defec- tive for IIIS, show tumor cell-like metabolic features, including a dedifferentiated state, accelerated aerobic glycolysis and impaired mitochondrial function. This feature among others, including the development of obesity- and hyperglycemia-related complications, is common between male ZDF rats and humans with type 2 diabetes associated with obesity. The fa mutation was discovered by Zucker and Zucker (1961, 1963) in crosses between Sherman and Merck stock M rats (13M strain). Type 2 diabetes mellitus (DM) leads to cardiac dysfunction irrespective of hypertension and coronary artery disease; this is called diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol. Male Zucker diabetic fatty fa/fa (ZDF) rats develop obesity and insulin resistance at a young age, and then with aging, progressively develop hyperglycemia.  |  1- Characterization of STZ-Induced Type 2 Diabetes in Zucker Fatty Rats. NIH Fatty males were more frequently affected than fatty females. Epub 2007 Sep 25. NIH Koh G, Seino Y, Usami M, Matsuo T, Ikeda H, Yamamoto T, Tsuda K, Taminato T, Imura H. Diabetes. 1988 Nov;37(11):1549-58. doi: 10.2337/diab.37.11.1549. Zimering MB, Grinberg M, Burton J, Pang K. Endocrinol Diabetes Metab J. Fujiwara T, Yoshioka S, Yoshioka T, Ushiyama I, Horikoshi H. Diabetes. The diabetic Zucker fatty rat A noninsulin-dependent diabetes appeared in fatty rats in our Zucker rat colony. ARTICLE Altered gap junctional communication and renal haemodynamics in Zucker fatty rat model of type 2 diabetes T. Takenaka & T. Inoue & H. Okada & Y. Ohno & T. Miyazaki & D. J. Chaston & C. E. Hill & H. Suzuki Received: 15 January 2011 /Accepted: 29 March 2011 /Published online: 15 May 2011  |  Most of them (~90%) belong to type 2 diabetes mellitus (T2DM), which is a common chronic metabolic disorder, and the number of cases has been reported to increase each year. Characterization of new oral antidiabetic agent CS-045. acting as an antidiabetic PPAR agonist. Potential mechanism for osseointegration of dental implants in Zucker diabetic fatty rats Zhonghao Liu , Wenjuan Zhou , Stefan Tangl , Shutai Liu , Xin Xu and Xiaohui Rausch-Fan British Journal of Oral and Maxillofacial Surgery, ... Diabetes interferes with the osseointegration of implants by deferring expression of fibronectin and integrin α5β1. A breeding program yielded a genetic pattern of diabetes consistent with a dominant gene not closely linked to the fatty gene. Dynamics of insulin sensitivity, -cell function, and -cell mass during the development of diabetes in fa/fa rats. The GK rat: a prototype for the study of non-overweight type 2 diabetes. Am J Physiol Endocrinol Metab. The content of pancreatic insulin was markedly decreased in the diabetic fatty rat relative to either the ad libitum or diet-restricted fatty rats. Arrested Net Hepatic Glycogen Flux in Zucker Diabetic Fatty Rats (ZDF) Acute changes in net hepatic g Acute changes in net hepatic glucose flux are tightly linked to regulation of net hepatic glycogen flux. Clipboard, Search History, and several other advanced features are temporarily unavailable. Epub 2019 Sep 6. NCI CPTC Antibody Characterization Program. Plasma insulin concentrations were unchanged relative to control fatty rats. Like NOD mice, biobreeding rats are used as an animal model for Type 1 diabetes. EPMA J. The mechanisms of adipogenic diabetes in Zucker diabetic fatty (ZDF) rats, a model of obesity complicated by diabetes, are reviewed. We discuss the diabetic features and complications found in ZDF rats and why these animals are widely used as a genetic model for obese type 2 diabetes. Curr Diabetes Rev. Yang Sheng Wu, Zhe Ming Li, Yi Tao Chen, Shi Jie Dai, Xiao Jie Zhou, Yuan Xiao Yang, Jian Shu Lou, Li Ting Ji, Yu Ting Bao, Ling Xuan, Lu Ning Lin, Chang Yu Li, " Berberine Improves Inflammatory Responses of Diabetes Mellitus in Zucker Diabetic Fatty Rats and Insulin-Resistant HepG2 Cells through the PPM1B Pathway ", Journal of Immunology Research,. Since then, fatty rats in our colony periodically expressed the di… Male Zucker diabetic fatty fa/fa (ZDF) rats develop obesity and insulin resistance at a young age, and then with aging, progressively develop hyperglycemia. Am J Physiol Endocrinol Metab.  |  The phenotypic changes resemble human type 2 diabetes associated with obesity and therefore the strain is used as a pharmacological model for type 2 diabetes. The initial characterization of a novel type 2 diabetes model derived from Zucker fatty (ZF) rats. Cocoa supplementation improves glucose metabolism in Zucker diabetic fatty (ZDF) rats via multiple mechanisms. Dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation. Improved metabolic status and insulin sensitivity in obese fatty (fa/fa) Zucker rats and Zucker Diabetic Fatty (ZDF) rats treated with the thiazolidinedione, MCC-555. USA.gov. Defective augmentation of glucose phosphorylation in response to a rise in plasma glucose in ZDF rats was associated with the coresidency of GKRP with GK in the cytoplasm in the midstage of diabetes, which was followed by a decrease in GK protein levels due to impaired posttranscriptional processing in the late stage of diabetes. Circulating Agonist Autoantibody to 5-Hydroxytryptamine 2A Receptor in Lean and Diabetic Fatty Zucker Rat Strains. Chen K, Wei X, Zhang J, Pariyani R, Jokioja J, Kortesniemi M, Linderborg KM, Heinonen J, Sainio T, Zhang Y, Yang B. J Agric Food Chem. 2014 Mar;10(2):131-45. doi: 10.2174/1573399810666140508121012. Mol Cell Biochem. Epub 2020 Aug 20. Production of glutamate, a key signal for IIIS, was decreased in the enlarged islets. REGULAR ARTICLE Zucker diabetic fatty rats, a model for type 2 diabetes, develop an inner ear dysfunction that can be attenuated by losartan treatment The aim of the current study was to predict changes in plasma methionine and homocysteine concentrations after simulated consumption of … Dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation. Abstract. This hyperglycemia is associated with impaired pancreatic β-cell function, loss of pancreatic β-cell mass, and decreased responsiveness of liver and extrahepatic tissues to the actions of insulin and glucose. Please enable it to take advantage of the complete set of features! Here, we investigated the severity of diabetic cardiomyopathy and myocardial remodelling in aged Zucker diabetic fatty (ZDF) rats… Zucker diabetic fatty (ZDF) rat provides a successful animal model to study the pathogenesis of T2DM. Importance of imparied insulin-gene expression in occurrence of diabetes in obese rats. The occurrence of a genetically based diabetes in a normally outbred colony underscores the importance of genetic traits that interact with obesity in determining diabetes in rodent models. NLM The evolution of diabetes in male leptin receptor-deficient Zucker diabetic fatty (ZDF) rats (ZDF/CrlCrlj) has resulted in it becoming a popular model for preclinical studies of type 2 diabetes, due to the fact that these rats exhibit disrupted islet architecture, β-cell degranulation and increased β-cell death (17, 18). This hyperglycemia is associated with impaired pancreatic β-cell function, loss of pancreatic β-cell mass, and decreased responsiveness of liver and extrahepatic tissues to the actions of insulin and glucose. A number of laboratories, including our own, have used obese Zucker and ZDF rats to investigate the consequences of insulin resistance and Type 2 diabetes on cardiac function ( 9 , 30 , 31 ). The diabetic trait in our colony was first reported in 1981. Zucker diabetic fatty rats An animal model for biomedical investigation is one in which normative biology, behavior, and pathological process can be studied and in which the phenomenon in one or more respects resembles the same phenomenon in humans [ 35 ]. doi: 10.1152/ajpendo.00255.2006. doi: 10.1152/ajpgi.00389.2018. 2020 Mar 9;10(1):90. doi: 10.1038/s41398-020-0767-0. 2020. Since no markers could be identified for heterozygous carriers and since affected fatty rats were 6 months old when diabetes appeared, the diabetic trait could not be sustained in our small colony. doi: 10.1152/ajpregu.1991.261.4.R912. Bohlen, H. G. (2004). Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes. Merdzo I, Rutkai I, Sure VNLR, Katakam PVG, Busija DW. This site needs JavaScript to work properly. 2020 Mar 9;10(1):90. doi: 10.1038/s41398-020-0767-0. Clipboard, Search History, and several other advanced features are temporarily unavailable. Delghingaro-Augusto V, Décary S, Peyot ML, Latour MG, Lamontagne J, Paradis-Isler N, Lacharité-Lemieux M, Akakpo H, Birot O, Nolan CJ, Prentki M, Bergeron R. Am J Physiol Endocrinol Metab. Hepatic Transcriptome Analysis Revealing the Molecular Pathogenesis of Type 2 Diabetes Mellitus in Zucker Diabetic Fatty Rats. The Zucker diabetic fatty (ZDF) rat, an inbred strain of obese Zucker fatty rat, develops early onset of insulin resistance and displays hyperglycemia and hyperlipidemia. First reported in 1981 Zucker fatty rat relative to either the ad libitum or diet-restricted fatty rats T, I. 6 ; 12 ( 2 ): H1086-H1092 463 million ) suffer from mellitus! 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