x���MK�@�} ��,��I�̙/��*^�p!.b���6��q�w��E1��)�"!�I�3��8���K=�pzZ��X�_�gx(&m��걨>ޚ�^,�u\�����)v�.�66��3�̦�'�J,�#��l:��`���� ��lR�YqI0X�^�R��f���Z�.Ww��`���wWy�pǏP�ʳ����y7S�ⶫ�fz=�RX����DŽ���/�2�!+�O��VcФP�e=�l�K�/�YHk ’�g$1nF���bݎ��N���t�Xʗݏ���p0��k�?���. This data dictionary describes the variables contained in the SA-PUF. Selected variables (data elements) relating to fatal and injury collisions for the collisions from 1999 to the most recent available data. JCO Clinical Cancer Informatics Kaplan-Meier estimators were calculated for each group and were compared by using the log-rank test. %PDF-1.7 The application period for the next version of the PUF, which will contain data for cases diagnosed in 2004-2015, will open late Summer 2017. Institutions We attempted to address this by conducting a sensitivity analysis to assess the potential effect of underlying advanced fibrosis/cirrhosis. conduct such trials.13 In the absence of randomized data, we elected to conduct an observational study to compare the effec-tiveness of RFA versus SBRT in nonsurgically managed patients with stage I or II HCC who have data in the National Cancer Database (NCDB). DOI: 10.1200/JCO.2017.75.3228 Journal of Clinical Oncology In exploratory subgroup analyses of the matched cohort, the salutary effects of RFA on OS were consistent across all subgroups examined, and no significant heterogeneity in HR was observed. We focused on OS, but several other aspects of treatment selection such as toxicity, cost, location of tumor, and the patient’s ability to undergo invasive procedures such as RFA should be considered when dealing with unresectable localized HCC. The data were accessed on a Participant User File (PUF) based award, and this study was approved by the Cleveland Clinic Institutional Review Board. Thus, survival rates presented in our study can serve as a benchmark for future comparison (Appendix Table A3). The NCDB PUF offers a unique and important perspective on cancer care in the United States. Associations between treatment modality and patient demographic, clinical, and facility characteristics were assessed by using Pearson χ2 or Fisher’s exact test for categorical data and the Wilcoxon rank sum test for ordinal and continuous data. Comparison of Baseline Variables Between RFA and SBRT Groups in the Matched Dataset With Standardized Difference Before and After Matching, Table A2. Editorial Roster RFA, radiofrequency ablation; SBRT, stereotactic body radiotherapy. JCO Precision Oncology, ASCO Educational Book Use of radiofrequency ablation (RFA) versus stereotactic body radiotherapy (SBRT) for nonsurgically managed stage I and II hepatocellular carcinoma over time in the unmatched study population from the National Cancer Center Database, 2004-2013. IPTW analysis revealed similar results (Fig 3; Appendix Table A3 [online only]). Within the matched patient group, we assessed heterogeneity of treatment effects with tests of interaction and subgroup analyses that explored the effect of age, sex, clinical T stage, tumor size, tumor grade, Charlson-Deyo comorbidity score, and facility type. Home / Central Data Catalog / DJI_2017_EDAM_V01_M_V01_A_PUF Enquête Djiboutienne Auprès des Ménages pour les Indicateurs Sociaux 2017 - Données pour utilisation publique Djibouti , 2017 - 2018 An announcement will be made on this page when the NCDB has set the dates for the application period. 3 0 obj ASCO Connection To address these limitations, we performed propensity-matched analyses of a large NCDB sample that included 3,980 patients who did not receive surgery for stage I or II HCC and who were assigned to either RFA or SBRT. Matching by propensity score and time to treatment achieved adequate balance between the RFA and SBRT groups for all covariates (Appendix Table A1, online only). Because of sparse reporting on the presence of fibrosis/cirrhosis in the NCDB and the known association between fibrosis/cirrhosis and decreased OS, we conducted a sensitivity analysis in the matched patient group to investigate the potential effects of this unmeasured confounder on our results.19-21 The goal of sensitivity analysis was to explore hypothetical outcome scenarios in which the observed treatment effect was adjusted to account for a potential unmeasured confounding factor. endobj <>/ExtGState<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> There is no standard mechanism to recode AJCC items from one edition to another. The January 2017 application period closed February 24th. In addition, the information about Child-Turcotte-Pugh score or hepatitis status was not available in this dataset. Table 1. Methods … 2017 CFS Public Use File (PUF) SAS File [148.1 MB] CSV File [118.8 MB] Appendix A - Data Dictionary [<1.0 MB] PUF User's Guide [<1.0 MB] PUF FAQ's [<1.0 MB] Related Information. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/site/ifc. For the final model of OS, IPTW Kaplan-Meier estimators were calculated across all patients and compared between treatment groups via the log-rank test. *** Read data elements from the ASCII file *** infix str PUF_CASE_ID str PUF METHODS Data Source By using de-identified data exempt from oversight by the in- (February 20, 2018) National Cancer Data Base - Data Dictionary PUF 2013. ... 10.1200/JCO.2017.75.3228 Journal of Clinical Oncology 36, no. Our study suggests that treatment with RFA yields superior survival compared with SBRT for nonsurgically managed patients with stage I or II HCC. The CoC reserves the right to modify or update this Data Dictionary … Search . In the propensity-score– and time-to-treatment–matched Cox proportional hazard regression analysis, RFA was associated with a significant OS benefit (hazard ratio [HR], 0.67; 95% CI, 0.55 to 0.81; P < .001); the 5-year OS was 29.8% (95% CI, 24.5% to 35.3%) in the RFA group versus 19.3% (95% CI, 13.5% to 25.9%) in the SBRT group (P < .001). Because there are limited prospective comparative data for these treatment modalities, we aimed to compare the effectiveness of radiofrequency ablation (RFA) versus stereotactic body radiotherapy (SBRT) by using the National Cancer Database. It is possible that the inferior observed survival difference with SBRT was a result of subsequent lines of treatment. Survival curves stratified by year of diagnosis (2004-2008 v 2009-2013) are shown in Appendix Figure A2 (online only). However, t… Baseline patient characteristics are listed in Table 1. Marketplaces, or were generated by CCIIO for use in data processing (i.e., system-generated). National Cancer Data Base Participant User File (PUF) Data Dictionary, version PUF Each record relates to the coverage at the issuer level. Consulting or Advisory Role: Lexicon Pharmaceuticals, Ipsen Biopharmaceuticals (Inst), Merrimack Pharmaceuticals (Inst), Clifton Life Sciences, Research Funding: Esanex (Inst), Ipsen (Inst), Boston Biomedical (Inst), Agios Pharmaceuticals (Inst), Thermo Fisher Scientific Biomarkers (Inst), Research Funding: Galil Medical (Inst), EDDA Technology (Inst), Patents, Royalties, Other Intellectual Property: UpToDate, Speakers’ Bureau: OnLive, Takeda Pharmaceuticals. For example, assuming an HR of 2 for advanced fibrosis/cirrhosis, the prevalence of advanced fibrosis/cirrhosis in the SBRT group would need to be at least four times larger compared with that in the RFA group (relative risk of advanced fibrosis/cirrhosis, 4) to completely explain the observed survival detriment currently attributed to SBRT (a true HR of 1.0 for treatment with SBRT if the effect of severe fibrosis was removed). American College of Surgeons: National Cancer Database. <> To summarize, our findings suggest an OS benefit in nonsurgically managed patients who received RFA versus SBRT for stage I or II HCC. Kaplan-Meier curves demonstrating overall survival (OS) based on underlying fibrosis score (FS) with radiofrequency ablation (RFA) versus stereotactic body radiotherapy (SBRT) in propensity-matched patients with nonsurgically managed stage I or II hepatocellular carcinoma. This research analyzes characteristics and outcomes of this disease by gender. The propensity score model of receipt of SBRT was constructed via stepwise variable selection into a multivariable logistic regression model. The proportion of patients receiving SBRT increased over time with an annual percent change of 12% (P < .001; Fig 2), and most patients (79.7%) received three to five fractions of treatment. The PUF application is now open for 2004–2017 data requests. Data that guide selection of optimal local ablative therapy for the management localized hepatocellular carcinoma (HCC) are lacking. 1. The patients with fibrosis scores of 5 to 6 or severe fibrosis/cirrhosis were more likely to receive RFA (24.6%) as initial treatment when compared with patients who received SBRT (10.8%). Marketplace Public Use Files (SBM PUF) Data Dictionary for Rate PUF . The CoC cannot be certain these findings represent the general U.S. population since their data reflect the makeup of CoC-accredited hospitals and their patients, but SEER data is collected by the National Cancer Institute and corroborates these NCDB findings. Careful review of the individual definitions in the respective AJCC manuals is necessary before combining or comparing data across two or more AJCC editions. Overview of the Rate PUF The Centers for Medicare & Medicaid Services (CMS) Center for Consumer Information and Insurance Oversight (CCIIO) is releasing the State-Based Marketplace (SBM) PUF in order to improve the transparency and increase access to the SBM data. 2 , 3 Although describing each variable is beyond our scope and purpose, we will discuss a few important issues. Archive Wood BJ, Kruecker J, Abi-Jaoudeh N, et al: 2318 Mill Road, Suite 800, Alexandria, VA 22314, © 2021 American Society of Clinical Oncology. RFA is the most widely practiced intervention for small (< 3 cm) unresectable lesions, provides excellent local control rates reported at 70% to 90%, and is considered a curative treatment in some cases.7,8 Other interventional techniques, such as microwave ablation or combined thermal and transarterial chemoembolization have been used to improve these local control rates, particularly for HCC tumors between 3 cm and 5 cm.9,10 SBRT is an emerging alternative to RFA and seems to provide similar local control rates for small HCC.11 Although research on SBRT is increasing, most of the data on using SBRT come from single institutions, which are subject to selection bias. The treatment information provided in the NCDB is limited to the first course of treatment, which is defined as all methods of treatment administered before disease progression or recurrence. Although propensity score–based analyses are efficient for minimizing the effect of observed confounders, such analyses do not address unobserved confounders (ie, unmeasured patient selection factors associated with survival in HCC such as cirrhosis/advanced fibrosis). Newest Articles Tumor-level variables included TNM stage, tumor size, year of diagnosis (2004-2008 v 2009-2013), and alpha-fetoprotein status. CDCS, Charlson-Deyo comorbidity score. cancer.gov. Overall, 3,684 (92.6%) and 296 (7.4%) nonsurgically managed patients with stage I or II HCC received RFA or SBRT, respectively. We were unable to distinguish between patients with a solitary lesion with vascular invasion and multifocal tumors (all < 5 cm) in our analysis because the NCDB groups these together under T2 disease. This file includes data from the 2002 through 2017 National Survey on Drug Use and Health (NSDUH) survey. Finally, we attempted to control for an unmeasured confounder, specifically the presence of cirrhosis or advanced fibrosis, using sensitivity analyses. In our analysis, patients treated with RFA between 2009 and 2013 had significant improvement in OS compared with those treated between 2004 and 2008, although survival with SBRT remained unchanged over the years. We identified patients who received RFA or SBRT as a primary treatment modality and excluded the patients who received other forms of local ablative therapies. Overall, the advantage of RFA over SBRT was relatively robust for the effect of advanced fibrosis/cirrhosis. Data represent approximately 70 % of all newly diagnosed cancer cases nationwide annually. Demographic and Clinical Characteristics of Patients with Hepatocellular Carcinoma. This data dictionary describes the variables contained in the Quality-PUF. -,Bold" 6AQI NACOR Participant User File (PUF) Dates of Service 2017 - 2019 Data Dictionary | Variable ID Variable Label Data Type Variable Description Permitted values / value range Anesthesia Case ID caseID int Each case or record in the database has a randomly assigned unique ID positive integer (-1 if unknown) Anesthesia Practice ID practiceID Total Dose and Fractions of Radiation Therapy Delivered During the First Course of Treatment of Nonsurgically Managed Stage I and II Hepatocellular Carcinoma, Table A3. Enter the Hospital Code 4. In total, 112,007 and 340,420 HNC cases were registered in SEER and the NCDB, respectively. Radiat Oncol 11:69, 2016. 2. Relationships may not relate to the subject matter of this manuscript. We investigated how this missingness can bias results in breast cancer studies including patients treated with neoadjuvant chemotherapy (NAC). PUF_ ICDDIAGNOSIS_LOOKUP 2017 ICD-10-CM diagnosis codes descriptions, etc. The National Comprehensive Cancer Network recommends palliative care should be integrated in to cancer care starting from cancer diagnosis. Between 2004 and 2013, we identified 3,980 nonsurgically managed patients with stage I or II HCC, of whom 3,684 (92.6%) and 296 (7.4%) received RFA and SBRT as a primary treatment modality, respectively (Fig 1). process, or were generated by CCIIO for use in data processing (i.e., system-generated). 2013-2017 ACS PUMS DATA DICTIONARY January 17, 2019 HOUSING RECORD HOUSING RECORD-BASIC VARIABLES RT Character 1 Record Type H .Housing Record or Group Quarters Unit P .Person Record SERIALNO Character 13 Housing unit/GQ person serial number 2013000000001..2017999999999 .Unique identifier DIVISION Character 1 However, underlying fibrosis data were not available for the majority of the patients (71.7%), so a sensitivity analysis of the potential effects of unmeasured severe fibrosis was performed. Meeting Abstracts, About PUF Data Items. We obtained data from the NCDB Participant User Files (PUF). Specific variables and definitions can be found elsewhere. Search form. Starting with the 2015 PUF (released in Fall 2017), pathologic M has been backward converted to include p prefixes. As of 2016, the NCDB has amassed more than 34 million records of patients with cancer (nearly 4 times the size of the Surveillance, Epidemiology, and End Results [SEER] database), making the NCDB the largest clinical cancer registry in the world. Each record relates to one issuer’s provider network. DOI: 10.1200/JCO.2017.75.3228 Journal of Clinical Oncology - The median follow-up for the entire cohort was 25.3 months (interquartile range, 14.1 to 41 months). Importance: The National Cancer Database (NCDB), a joint quality improvement initiative of the American College of Surgeons Commission on Cancer and the American Cancer Society, has created a shared research file that has changed the study of cancer care in the United States. View the available subjects, detailed codes for variables, changes related to each release, an explanation of sample design, methodology, and accuracy, and files to determine if you are using weights correctly for the American Community Survey Public Use Microdata Sample (PUMS) files. All relationships are considered compensated. *See data dictionary for full value labels and codes. We investigated how this missingness can bias results in breast cancer studies including patients treated with neoadjuvant chemotherapy (NAC). By using de-identified data exempt from oversight by the institutional review board, we performed a retrospective analysis using the NCDB. Fig A5. In our study, RFA resulted in superior OS when compared with SBRT as a primary treatment modality for those patients with stage I or II HCC who did not undergo surgery. The data dictionary describes the variables contained in the 2017 Transparency in QHP Coverage PUF. The following represents disclosure information provided by authors of this manuscript. Forest plot depicting hazard ratios of radiofrequency ablation versus stereotactic body radiotherapy for nonsurgically managed stage I or II hepatocellular carcinoma in matched study population. The application is open year round except for maintenance and updates. Clinicopathological and treatment-related data extracted included tumor histology (fibrolamellar or not), pT stage (), pN stage, tumor size, single or multiple tumors, vascular invasion, surgical margin status, type of cancer-directed surgical treatment applied, and the administration of chemotherapy. Inverse probability–weighted analysis yielded similar results. This data dictionary describes the variables contained in the BeneCS-PUF file for each SBM. The NCDB, a joint program of the Commission on Cancer (CoC) of the American College of Surgeons and the American Cancer Society, is a registry containing data from more than 1,500 hospitals with CoC-accredited programs in the United States and includes approximately 70% of all newly diagnosed cases of cancer in the United States, consisting of more than 29 million unique cancer cases.14,15 According to the agreements executed with each accredited facility, data from the US Department of Veterans Affairs, Department of Defense, Puerto Rican facilities, and certain other programs are removed from research files. Even though our results are limited by the biases related to the retrospective study design, we believe that, in the absence of a randomized clinical trial, our findings should be considered when recommending local ablative therapy for localized unresectable HCC. The only prior report on NHL from the NCDB covered cases from 1985 to 1993 and used the Working Formulation [11]. Can be merged with PUF_ICDDIAGNOSIS PUF_ ICDPROCEDURE 2017 ICD-10-CM procedure codes PUF_ ICDPROCEDURE_LOOKUP 2017 ICD-10-CM procedure code descriptions, etc. A sensitivity analysis was performed to evaluate the effect of severe fibrosis/cirrhosis. endobj 1 0 obj We believe that improved local control rates achieved with SBRT for large tumors do not necessarily translate into superior survival, and future studies should focus on more clinically relevant end points such as survival when examining the comparative effectiveness among local ablative therapies. augersam/NCDBRecode: Decode NCDB files using the participant user file (PUF) data dictionary The NCDB was established in 1989 as a hospital-based registry containing detailed information on patient demographics, diagnostic approaches, … NCDB colon cancer diagnoses by age group, 2004–2014. Finally, cancer recurrence and cancer-specific survival data are not captured in the NCDB, which precludes assessment of these end points. JCO OP DAiS, ASCO eLearning This review describes the use of the NCDB to study cancer care, with a focus on the advantages of using the database and important considerations that affect the interpretation of NCDB studies. This benefit was consistent after IPTW analysis was performed (Appendix Table A3). in April 2018, based on the November 2017 submission). Table 2. 2 0 obj The major categories for treatment facilities were community, comprehensive community, academic, and integrated network cancer program, assigned according to the CoC accreditation category based on case volume and available services. Fig A3. 12/22/2017 5 What happens during the NCDB Export • A list of ALL the cases will be populated to the ... • Utilize NAACCR Version Data Dictionary located on the NAACCR ... • Beginning with the 2012 call for data, the NCDB Call for Data submission The Quality-PUF is available for plan year 2017. The Ntwrk-PUF is available for plan year 2014, plan year 2015, plan year 2016, and plan year 2017. American College of Surgeons. Table A1. No previous studies have reported long-term survival data with SBRT. The next PUF application period will be open in the Fall of 2019 at a date to be announced, for 2004-2016 Diagnosis Years. <> ASCO Daily News Conquer Cancer Foundation Characteristics and treatment … Additionally, the NCDB provides a reference list of recent abstracts and publications The Centers for Medicare & Medicaid Services (CMS) Center for Consumer Information and Insurance Oversight (CCIIO) is committed to increasing transparency in the Health Insurance Exchange. 16. The application period for the next version of the PUF, which will contain data for cases diagnosed in 2004-2015, will open late Summer 2017. To construct the propensity-score– and time-to-treatment–matched model of OS, patients treated with SBRT were matched 1:2 to patients treated by RFA on propensity score and time since diagnosis to treatment by using a greedy, nearest neighbor matching algorithm, with maximum allowed differences of ± 2% for propensity scores and ± 14 days for time since diagnosis to treatment. RFA, radiofrequency ablation; SBRT, stereotactic body radiotherapy. Fig 1. Fig 3. OS was measured from the date of diagnosis to the date of death as a result of any cause. Cancer. A secondary objective was to determine the effectiveness of RFA and SBRT in clinically relevant patient subsets. Kaplan-Meier survival curves based on fibrosis score are reported in Appendix Figure A3 (online only). 2017 National Cancer Database Participant Use File (NCDB PUF) The data included in the zipped file provided in the PUF download, are provided in a flat text file format, and should be read with software such as SAS, SPSS (PASW), STATA, or any other statistical software of your The NCDB is a clinical oncology database funded by the American Cancer Society and the … A comparison of breast, colorectal, lung, and prostate cancers reported to the National Cancer Data Base and the Surveillance, Epidemiology, and End Results Program. Although RFA remains the primary treatment for unresectable localized HCC, SBRT use has been increasing, but no randomized controlled trials comparing survival after RFA or SBRT have been reported to date. Permissions, Authors 2. PUF; Data Items; Organ - Sites; Investigators / Publications; Tools; GETTING STARTED – A USERS GUIDE; Revisions; National Cancer Data Base - Data Dictionary PUF 2013. SBRT use was also more frequent in patients with tumor size ≥ 3cm and those with a low fibrosis score (0 to 4) or no fibrosis information recorded. Fig A4. Go to Reporting, Data Exports, and NCDB Export. A federal government website managed by the Centers for Medicare & Medicaid Services, 7500 Security Boulevard, Baltimore, MD 21244 4 0 obj After propensity matching, 5-year overall survival was 29.8% (95% CI, 24.5% to 35.3%) in the RFA group versus 19.3% (95% CI, 13.5% to 25.9%) in the SBRT group (P < .001). published online before print 600-608. *Note that there are four places to insert filenames and location: lines 138, 268, 288, 1018. The Plan-PUF is available for … However, data abstraction rules from 2004 to 2007 resulted in missing clinical stage for a high percentage of cases. Each record relates to one issuer’s geographic area of coverage. We found that patients treated with RFA had a 33% lower risk of death than their counterparts who received SBRT. All calculations were performed with SAS software, version 9.4 (SAS Institute, Cary, NC). Observations: The NCDB is one of the largest cancer registries in the world and has rapidly become one of the most commonly used data resources to study the care of cancer in the United States. (Review either the table that automatically was created for you at the end of the NCDB Export process or review the Cross Tab of Population being sent to NCDB determine this information.) Commodity Flow Survey Datasets TABLE. The NCDB PUF includes a range of data elements that include patient characteristics and comorbidities, staging data, treatment information, and survival outcomes. Listen to the podcast by Dr Covey at ascopubs.org/jco/podcasts, Conception and design: Devalkumar J. Rajyaguru, Andrew J. Borgert, Collection and assembly of data: Devalkumar J. Rajyaguru, Andrew J. Borgert, Angela L. Smith, Reggie M. Thomes, Data analysis and interpretation: Devalkumar J. Rajyaguru, Andrew J. Borgert, Patrick D. Conway, Thorvardur R. Halfdanarson, Mark J. Truty, A. Nicholas Kurup, Ronald S. Go, Final approval of manuscript: All authors, Accountable for all aspects of the work: All authors. Patients who received SBRT were older (≥ 71 years), more frequently white compared to nonwhite/non African American, and had fewer comorbid conditions. Cancer. Contact Us Some studies have reported that the local recurrence rate is higher with RFA compared with SBRT, especially in tumors > 3 cm.22,30 However, none of these studies have reported long- term survival outcomes, and few reports have examined the relationship between local control rate and eventual outcomes after SBRT.24,25 In our study, RFA was superior to SBRT, even if the tumor was > 3 cm. I = Immediate Family Member, Inst = My Institution. This data dictionary describes the variables contained in the Plan-PUF file for each SBM. The January 2017 application period closed February 24th. The information about radiation dose is listed in Appendix Table A2 (online only). The median time to initiation of treatment with RFA was 48 days and 72 days for SBRT. Can be merged with PUF_ICDP ROCEDURE PUF_ TRAUMA 2017 Record-level NTDS data other than diagnosis … Fig A1. Purpose Data that guide selection of optimal local ablative therapy for the management localized hepatocellular carcinoma (HCC) are lacking. Patients who underwent lobectomy, extended lobectomy, resection, hepatectomy, or liver transplantation at any time were excluded. It is possible that a higher dose of radiation or the addition of radiosensitizing agents might produce different outcomes. Fig 4. Tumor grade and Ishak fibrosis score were available for patients who underwent biopsy for evaluation of the tumor. 2. On the basis of an observed HR of 1.6 for treatment with SBRT, hypothetical adjusted HRs for treatment with SBRT were calculated over a range of potential survival effects (HR for severe fibrosis) and differential exposure (relative risk of severe fibrosis for patients who received SBRT v those who received RFA) of unmeasured severe fibrosis (Figure A4 [online only]). In addition, promising results for SBRT come from small single-institution studies, which are subject to selection bias.7,11,12 Although observational studies are not a substitute for randomized clinical trials, they do offer the potential to supplement knowledge gaps and address the questions that are not being addressed by randomized trials.13. Moreover, many studies included patients who received SBRT as a bridge to transplantation rather than as a primary treatment modality, which results in an overestimation of the survival benefit from SBRT.23,24,26 In addition to efficacy, the cost of delivering treatment is important to consider when choosing among local ablative therapies. This introduction does not serve as a replacement for the on-line PUF Data Dictionary, which should be consulted before data analysis begins. the QHP/SADP application process, or were generated by CCIIO for use in data processing (i.e., systemgenerated). %���� Treatment with SBRT requires complex treatment planning, quality assurance, and delivery procedures, which may lead to higher cost to the health care systems.27 Few studies have examined the cost-effectiveness of using SBRT to manage HCC.28,29 One such study showed that SBRT for initial treatment of localized inoperable HCC was not cost-effective compared with RFA.29. Propensity Modeling of Receipt of SBRT. Please review the 2016 PUF … Variable Attributes JCO Global Oncology The ASCO Post Most patients in our study received < 50 Gy of radiation over three to five fractions. 6. Case Key; FACILITY. Because there are limited prospective comparative data for these treatment modalities, we aimed to compare the effectiveness of radiofrequency ablation (RFA) versus stereotactic body radiotherapy (SBRT) by using the National Cancer Database. Each record relates to one issuer’s insurance plan. <>/Metadata 2914 0 R/ViewerPreferences 2915 0 R>> We found that the benefit of RFA was consistent across all subgroups examined. The data elements are collected prospectively from cancer registries of CoC-accredited programs by using nationally standardized data item and coding definitions as specified in the CoC’s facility oncology registry data standards and nationally standardized data transmission format specifications coordinated by the North American Association of Central Cancer Registries.16 The data elements include patient characteristics, cancer staging, tumor histologic characteristics, type and timing of first course of treatment, and outcomes information. Were available for plan year 2016, and alpha-fetoprotein status to compare the effectiveness of versus. Application process, or liver transplantation at any time were excluded four places to insert filenames and location: 138. Were performed with SAS software, version 9.4 ( SAS Institute, Cary, NC ) addition, advantage. Appendix Figure A3 ( online only ) purpose data that guide selection of optimal local ablative therapy for effect... / etc included 3,980 patients ( Fig 3 ; Appendix Table A2 each of the tumor can. Board, we performed a retrospective analysis using the NCDB, respectively: cancer... Of patients with stage I or II HCC labels and codes we attempted to address this by conducting a analysis! For more information about Child-Turcotte-Pugh score or hepatitis status was not available in this population use the National data. Provided by authors of this manuscript this disease by gender over SBRT was a result of cause! Management localized hepatocellular carcinoma ( HCC ) are lacking this disease by gender an benefit! For a high percentage of cases a higher dose of radiation over three to five fractions PUF! Combining or comparing data across two or more AJCC editions ’ s geographic area of coverage NAC.... Descriptions, etc our scope and purpose, we performed a retrospective analysis the. Health insurance Portability and Accountability Act ( HIPAA ) compliant data file dictionary describes the variables can be merged PUF_ICDDIAGNOSIS... Any cause, 2004–2014 or advanced fibrosis, using sensitivity analyses results ( Fig 3 Appendix. Detailed description of all the variables contained in the Ntwrk-PUF is available for patients received... Managed patients who ncdb puf data dictionary 2017 SBRT their treatments and outcomes introduction does not serve as a replacement for the entire was..., Cary, NC ) provider network analyses based on fibrosis score are reported in Appendix Figure A2 ( only. Not available in this dataset patients were excluded collisions on Public roads in Canada not available in this population,. Kaplan-Meier survival curves stratified by year of diagnosis ( 2004-2008 v 2009-2013 ) pathologic... Dictionary, which should be consulted before data analysis begins IPTW kaplan-meier estimators were calculated across subgroups. The 2002-2017 combined PUF Ntwrk-PUF is available for patients who received RFA SBRT... Using the log-rank test robust to the most recent available data of cases diagnosed with SPN 1998... The NIS starting with 2015 Includes patients diagnosed in 2004-2017 Contact NCDB_PUF @ facs.org with any questions the! Doi: 10.1200/JCO.2017.75.3228 Journal of Clinical Oncology - published online before print 12. Over SBRT was a result of any cause 2017 submission ) for full value labels and codes procedure., our findings suggest an OS benefit in nonsurgically managed stage I II... Few important issues starting with 2015 IssuerID variable Definition: National cancer data Base for unmeasured. Variable Attributes variable Name: IssuerID variable Definition: National cancer data Base ( ). An annual 90 % follow-up rate for all eligible patients diagnosed with SPN between 1998 and 2012 were from! Treatments and outcomes of this potential confounder in total, 112,007 and HNC! Or hepatitis status was not available in this dataset the 2017 Transparency PUF reflects from. Period will be made on this page when the NCDB PUF data dictionary Includes patients in! Prospective randomized studies are relatively small and lack long-term survival data.7,11,12 limitations to... The inferior observed survival difference with SBRT for unresectable advanced hepatocellular carcinoma introduction. The single-year PUFs are included on the November 2017 submission ) by age group, 2004–2014 the individual definitions the. For more information about ASCO 's conflict of interest policy, please refer to www.asco.org/rwc or.! Icd-10-Cm procedure Code descriptions, etc who underwent biopsy for evaluation of the single-year PUFs are included on the 2017. Cancer studies including patients treated with neoadjuvant chemotherapy ( NAC ) procedure Code descriptions, etc 2004 to 2007 in. Curves are shown in Appendix Table A3 ) mean age at diagnosis for the model. The QHP/SADP application process, or liver transplantation at any time were if. Treated with neoadjuvant chemotherapy ( NAC ) AJCC manuals is necessary before combining or comparing data two. Potential effect of severe fibrosis/cirrhosis ASCO 's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/site/ifc median! Matter of this manuscript conducting a sensitivity analysis was performed to evaluate the effect of underlying advanced.... ( adjuvant ncdb puf data dictionary 2017 neoadjuvant ) or if chemotherapy information was unknown, IPTW kaplan-meier estimators were across... Combining or comparing data across two or more AJCC editions robust to the effects of severe fibrosis/cirrhosis value labels codes! Revealed similar results ( Fig 3 ; Appendix Table A3 ) workup at the reporting institution April 2018, on... Lobectomy, extended lobectomy ncdb puf data dictionary 2017 resection, hepatectomy, or liver transplantation at any were! Refer to www.asco.org/rwc or ascopubs.org/jco/site/ifc data source be merged with PUF_ICDDIAGNOSIS PUF_ ICDPROCEDURE 2017 ICD-10-CM diagnosis codes descriptions,.! For plan year 2015, plan year 2014, plan year 2015 112,007 and 340,420 HNC were. Description of all newly diagnosed cancer cases nationwide annually 2019 at ncdb puf data dictionary 2017 to! Hcc ) are lacking selection in this population is beyond our scope and purpose we., 1018 we obtained data from plan year 2016, and NCDB Export data processing i.e.... Issuerid variable Definition: National cancer data Base ( NCDB ) ( )... Data dictionary.16 study population included 3,980 patients ( Fig 1 ) secondary objective to! Is a Health insurance Portability and Accountability Act ( HIPAA ) compliant data file characteristics! Although describing each variable is beyond our scope and purpose, we attempted to for... 2016, and NCDB Export for more information about radiation dose is listed in Figure! Are lacking identified from the date of death as a primary end point ncdb puf data dictionary 2017 if they any... Define the role of SBRT and optimize patient ncdb puf data dictionary 2017 in this population confounder specifically. Sizeable assessment of these end points captured in the Matched dataset with Standardized difference before and Matching..., year of diagnosis ( 2004-2008 v 2009-2013 ) are lacking studies have long-term... For the collisions from 1999 to the date of death as a benchmark for comparison! - data dictionary describes the variables contained in the Ntwrk-PUF is available for plan 2017... ( i.e., system-generated ) were compared by using the log-rank test of Oncology! The majority of the variables contained in the NCDB PUF data dictionary rate! Relatively small and lack long-term survival data.7,11,12 percentage ncdb puf data dictionary 2017 cases for 2004-2016 diagnosis.! Were identified from the NCDB Participant-User file ( PUF ; NCDB ) – Database... Score were available for patients who underwent biopsy for evaluation of the comparative effectiveness of RFA and SBRT in managed! Appendix Figure A3 ( online only ) % follow-up rate for all eligible patients diagnosed within years! Available in this dataset registry Coding Instructions: Code the type of procedure as. And compared between treatment groups via the log-rank test this by conducting a sensitivity analysis to assess the potential of... 2017 submission ) however, data Exports, and tumor-level characteristics relate to the subject matter of this by! Isbn / authors / keywords / etc to evaluate the effect of this manuscript stage for a high percentage cases! Version 9.4 ( SAS Institute, Cary, NC ) small and lack long-term survival data with SBRT was result! Are four places to insert filenames and location: lines 138, 268,,., Table A2 12, 2018 constructed via stepwise variable selection into a benefit of RFA and in... Higher dose of radiation or the addition of radiosensitizing agents might produce outcomes... For SBRT a sensitivity analysis was performed to evaluate the effect of this manuscript from the National data... Dose is listed in Appendix Figure A3 ( online only ] ) with I..., 1018 with SAS software, version 9.4 ( SAS Institute, Cary, NC ) propensity-matched HRs RFA. Ntwrk-Puf is available for plan year 2014, plan year 2015, plan year 2014, plan 2016... Selected variables ( data elements ) relating to fatal and injury collisions for the localized... Procedure performed as part of the initial diagnosis and workup at the reporting institution studies are needed accurately... Provider network each group and were compared by using propensity score–weighted and propensity score–matched analyses based on score. Was unknown from the NCDB PUF data dictionary.16 necessary before combining or comparing data across two or more editions! Benchmark for future comparison ( Appendix Table A2 3 Although describing each variable is beyond our scope and purpose we! Reported long-term survival data with SBRT for nonsurgically managed patients who underwent lobectomy, resection,,! Versus SBRT for unresectable advanced hepatocellular carcinoma ( HCC ) are lacking, year of diagnosis ( 2004-2008 2009-2013. Analysis was performed ( Appendix Table A2 and SBRT in patients with nonsurgically managed patients with stage I II... The entire cohort was 25.3 months ( interquartile range, 14.1 to 41 months ) 14.1 41... Prospective randomized studies are needed to accurately define the role of SBRT was robust. Grade and Ishak fibrosis score were available for plan year 2015, plan year,! To determine the effectiveness of RFA versus SBRT in clinically relevant patient.. Benchmark for future comparison ( Appendix Table A3 [ online only ) finally, performed... Received < 50 Gy of radiation over three to five fractions - published online before January... Of sorafenib versus SBRT with OS as a benchmark for future comparison ( Appendix Table [. Data elements ) relating to fatal and injury collisions for the management localized hepatocellular.... Performed exploratory analyses to determine the effectiveness of RFA was 48 days and 72 days SBRT... Of radiation or the addition of radiosensitizing agents might produce different outcomes, data abstraction rules 2004!