Identical copies of this gene reside on the pseudoautosomal regions of the X and Y chromosomes. It is useful for tracking sequence updates.
The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the inner mitochondrial membrane, transports ADP and ATP across the membrane. Here, we show that equivalent mutations in … The mechanism of the Ant1-induced pathologies is highly debated. Adenine nucleotide translocase (or adenine nucleotide translocator or Ant) is the most abundant protein in mitochondria, accounting for up to 10% of total mitochondrial protein content . Adenine nucleotide translocator; Solute carrier family; References Validated: WB, ICC/IF, IHC. Nutrients.The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) Adenine nucleotide translocase Imported Submitted name: Slc25a5-prov protein Imported. Mutations within Ant1 have been shown to produce a syndrome of chronic progressive external ophthalmoplegia (CPEO) in humans. Epub 2019 Apr 10. The information is filed in different subsections. Here, we describe the characterization of adenine nucleotide translocase-1 (ANT-1), a central component of the permeability transition pore, which was identified using such a screen. Adenine nucleotide translocases (ANTs) are mitochondrial proteins encoded by nuclear DNA that catalyze the exchange of ATP generated in the mitochondria for ADP produced in cytosol. This paper briefly overviews experimental results focusing on the role of ANT in the mitochondrial permeability transition and It is an antiporter. HHS Through its PPIase ability, the protein interacts with and induces a conformational change in adenine nucleotide translocase (ANT), the other MPTP component. Please enable it to take advantage of the complete set of features! Curr Med Chem 2003, 10(16): 1507 1525. (2010) showed that MeCP2 (300005) cooperates with YY1 (600013) in repressing the ANT1 gene, encoding a mitochondrial adenine nucleotide translocase. Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max),
Information which has been generated by the UniProtKB automatic annotation system, without manual validation.
31. The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the innter mitochondrial membrane, transports ADP and ATP across the membrane. Adenine Nucleotide … Recent studies have shown that mutations in the adenine nucleotide translocase (Ant) cause aging-dependent degenerative cell de ath (DCD) in yeast, which is sequentially manifested by inner membrane stress, mitochondrial DNA (mtDNA) loss, and progressive loss of cell viability. Phosphate translocase is also located in the inner mitochondrial membrane.However UniProtKB may contain entries with identical sequences in case It is encoded by the nuclear DNA, synthesized in cytosol, imported into mitochondria, and finally inserted into the inner membrane [ 9 – 11 ]. Adenine Nucleotide Translocase immunoprecipitation using antibody ab109864/MS101c crosslinked to protein G-agarose beads as product ab109713 Protocols. At 0.2–2 mM To further analyze the molecular mechanisms of action of concentrations, lovastatin inhibited the IPP accumulation and ApppI, we next studied its effect in the isolated rat liver the ApppI production (Po0.001) in a dose dependent manner … The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the inner mitochondrial membrane, transports ADP and ATP across the membrane. (net Charge Of -1) Into The Mitochondrial Matrix And ATP-Mg]" (net Charge Of -2) Out Of The Matrix. In pathological conditions, F0F1‐ATPase hydrolyzes ATP in an attempt to maintain mitochondrial membrane potential. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.
Protein sets from fully sequenced genomes. (Recall that these adenine nucleotides are negatively charged: ADP 3-and ATP 4-.) Adenine nucleotide translocase (ANT), a mitochondrial protein that facilitates the exchange of ADP and ATP across the mitochondrial inner membrane, plays an essential role in cellular energy metabolism. The hepatoprotective effects of adenine nucleotide translocator 2 against aging and oxidative stress. ADP/ATP translocase 3, also known as solute carrier family 25 member 6, is a protein that in humans is encoded by the SLC25A6 gene. Importantly, ANT1 mRNA levels are increased in human and mouse cell lines devoid of MeCP2, in Rett syndrome (312750) patient fibroblast, and in the brain of MeCP2-null mice. 1998a). You are using a version of browser that may not display all the features of this website. In addition to its normal function, the adenine nucleotide translocase (ANT) forms the inner membrane channel of the mitochondrial permeability transition pore (MPTP). ELISA: Adenine Nucleotide Translocator 2 Antibody (1D7) [H00000292-M01] - Detection limit for recombinant GST tagged SLC25A5 is 3 ng/ml as a capture antibody. Adenine nucleotide translocase 1 (Ant1) is a mitochondrial inner membrane protein involved in ATP/ADP exchange. The characteristics of the inhibition of the adenine nucleotide translocase by oleoyl-CoA were similar qualitatively and quantitatively in isolated mitochondria and "inside out" submitochondrial particles. (2018) reported that the FAM173A gene encodes a 235-amino acid protein. Rabbit Polyclonal Anti-Adenine Nucleotide Translocator 2 Antibody. Human ANT presents four isoforms (ANT1-4), each with a specific expression depending on the nature of the tissue, cell type, developmental stage and status of … Adenine nucleotide translocase-2 (ANT2) is an oncogenic mitochondrial membrane–associated protein. The algorithm is described in the ISO 3309 standard. Ohkubo S, Mancinelli R, Miglietta S, Cona A, Angelini R, Canettieri G, Spandidos DA, Gaudio E, Agostinelli E. Int J Oncol. Transient overexpression of ANT3 resulted, … Cell Biol. In vitro the ADP/ATP translocase can exchange pyrophosphate for adenine nucleotides under special conditions, but the affinity of the carrier for pyro-phosphate is very low compared with that for adenine nucleotides, so it is doubtful that this unusual exchange … 2019 Jun;54(6):2080-2094. doi: 10.3892/ijo.2019.4780. from the sequence. Synonyms: Ant1 Imported, slc25a5 Imported. Using thermodynamic assumptions and computer modeling, we established that mitochondrial membrane potential can be more negative than the reversal potential of the adenine nucleotide translocase (ANT) but more positive than that of the F 0 F1‐ATPase. Bcl-2 is a prosurvival factor that reportedly prevents the nonspecific permeabilization of mitochondrial membranes, yet enhances specific ADP/ATP exchange by these organelles. Keywords:cyclophilin, … Furthermore, all channel proteins are the examples of uniports, and Na/glucose symporter is an example of a symport… The mechanism of the Ant1-induced pathologies is highly debated. Rabbit anti Rat Adenine Nucleotide Translocator 1 antibody recognizes ADP/ATP translocase 1, also known as Adenine Nucleotide Translocator 1 (ANT1), ADP,ATP carrier protein 1 or Solute carrier family 25 member 4. Order Details 100% Guarantee on every product.It should be noted that while, in theory, two different sequences could has long been assumed that the ADP/ATP translocase is the only adenine nucleotide transporter in mitochon-dna. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Gene names i: Name:slc25a5.L Imported. See also. Adenine nucleotide translocase (ANT) was found to be the only protein in the mitochondrial membranes exhibiting a detectable age-associated increase in carbonyls. It also includes information pertinent to the sequence(s), including length and molecular weight. It doesn’t matter whether the Abreview is positive or negative, we would just really … was revealed by studying some mutant forms of adenine nucleotide translocase, which causes aging-dependent cellu-lar degeneration. We have transfected HeLa cells with the three human ANT isoforms to compare their potential as inducers of apoptosis. DNA Data Bank of Japan; a nucleotide sequence database, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, Database of comparative protein structure models, ProtoNet; Automatic hierarchical classification of proteins, MobiDB: a database of protein disorder and mobility annotations,
Information inferred from a combination of experimental and computational evidence, without manual validation.
In summary, acetylation of mitochondrial proteins, and in particular the adenine nucleotide translocase ANT1, is abundant in human skeletal muscle mitochondria and correlated with insulin sensitivity. USA.gov. The adenine nucleotide transporter 1 (Ant1) gene encodes an inner mitochondrial membrane protein that transports ADP into mitochondria and ATP from mitochondria to the cytosol. Title: The Adenine Nucleotide Translocase: A Central Component of the Mitochondrial Permeability Transition Pore and Key Player in Cell Death VOLUME: 10 ISSUE: 16 Author(s):Andrew P. Halestrap and Catherine Brenner Affiliation:Department ofBiochemistry, School of Medical Sciences, University of Bristol, Bristol,BS8 1TD, UK. The recognition of two specific binding sites of the adenine nucleotide translocase by palmitoyl CoA in bovine heart mitochondria and submitochondrial particles. Gene names i: Name:slc25a5.L Imported. Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane. Summary. In this study, we model the ADP–ATP exchange rate during steady state mediated by ANT as a function of mitochondrial membrane potential (ΔΨ m ). Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. 1998 Jan 23;422(1):36-42. doi: 10.1016/s0014-5793(97)01594-9. The chapter illustrates that the adenosine diphosphate (ADP)/adenosine triphosphate (ATP) … is extremely low. This is known as the 'taxonomic identifier' or 'taxid'.,This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. Missense mutations in the Ant1 isoform cause autosomal dominant Progressive External Ophthalmoplegia (adPEO), cardiomyopathy and myopathy.
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